Afonso VI ( ; English Alphonzo or Alphonse), or Affonso (Old Portuguese), (21 August 1643 – 12 September 1683) was the twenty-second (or twenty-third according to some historians) king of Portugal and the Algarves, the second of the House of Braganza, known as "the Victorious" (Portuguese o Vitorioso).

At the age of three, Afonso suffered an illness that left him paralyzed on the left side of his body, as well as leaving him mentally unstable. His father created him 10th Duke of Braganza.

After the 1653 death of his eldest brother Teodósio, Prince of Brazil, Afonso became the heir-apparent to the throne of the kingdom. He received also the crown-princely title 2nd Prince of Brazil.

He succeeded his father (João IV) in 1656 at the age of thirteen. His mother, (Luisa of Medina-Sidonia) was named regent in his father's will. His mental instability and paralysis, plus his disinterest in government, left his mother as regent for six years, until 1662. Afonso oversaw military victories over the Spanish at Ameixial (8 June 1663) and Montes Claros (17 June 1665), culminating in the final Spanish recognition of Portugal's independence on 13 February 1668 in the Treaty of Lisbon. Colonial affairs saw the Dutch conquest of Jaffnapatam, Portugal's last colony in Sri Lanka (1658) and the cession of Bombay and Tangier to England (23 June 1661) as dowry for Afonso's sister, Catherine of Braganza who had married King Charles II of England. English mediation in 1661 saw the Netherlands acknowledge Portuguese rule of Brazil in return for uncontested control of Sri Lanka.

In 1662, the Count of Castelo Melhor saw an opportunity to gain power at court by befriending the king. He managed to convince the king that his mother was out to steal his throne and exile him from Portugal. As a result, Afonso took control of the throne and his mother was sent to a convent.

He was married to Marie Françoise of Nemours, the daughter of the Duke of Savoy, in 1666, but this marriage would not last long. Marie Françoise, or Maria Francisca in Portuguese, filed for an annulment in 1667 based on the impotence of the king. The Church granted her the annulment, and she married Afonso's brother, Pedro, Duke of Beja, (future (Peter II)). That same year, Pedro managed to gain enough support to force the king to relinquish control of the government and he became Prince Regent in 1668. Afonso was exiled to the island of Terceira in the Azores for seven years, returning to mainland Portugal shortly before he died at Sintra in 1683.

His trial is the base for João Mário Grilo's 1990 film, The King's Trial (O Processo do Rei).

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