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α-Ethyltryptamine (αET, AET; Monase), also known as etryptamine, is a psychoactive drug and member of the tryptamine chemical class. Originally believed to exert its effects predominantly via monoamine oxidase inhibition, it was investigated as an antidepressant by Upjohn Chemical Company under the name Monase, but was withdrawn from commercial use after a year due to the unacceptable occurrence of agranulocytosis. αET was abused as a designer drug in the 1980s, and was subsequently added to the United Statesmarker Schedule I list of illegal substances in 1993.

αET is structurally and pharmacologically related to α-methyltryptamine (αMT), but its effects are slightly different. In contrast to αMT, αET is less stimulating and hallucinogenic, and its effects resemble more those of entactogens like MDMA ("Ecstasy"). Similarly to MDMA, αET has been demonstrated to be a serotonin, norepinephrine, and dopamine releasing agent in scientific research, with primary actions on the former neurotransmitter, as well as a serotonergic neurotoxin. It also acts as a non-selective serotonin receptor agonist.

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