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Clarence and Carl Aguirre (born April 21 2002) are former conjoined twins born in Silay Citymarker, Philippinesmarker. They were conjoined at the top of the head (vertical craniopagus). In 2003 they were brought to the United Statesmarker by their mother Arlene in the hopes of having them surgically separated. A revolutionary new process was used in separating the twin boys. Because "marathon" surgical operations have historically led to a high rate of mortality and morbidity, Clarence and Carl's doctors chose to separate them in several smaller operations, allowing the twins to recuperate after each surgery.

In October 2003, tissue expanders (pouches filled with saline) were implanted under the boys' scalps. This is common practice in separating conjoined twins, as it creates more skin that can be used to cover the twins' wounds after separation. Over the next ten months, the brothers underwent several more surgeries to tease apart their joined skulls and brains. On August 4 2004, the final surgery was completed. All of these surgeries were performed at Montefiore Medical Center in the Bronxmarker, New Yorkmarker by a team lead by Dr. James T. Goodrich, a pediatric neurosurgeon. They received most of their post-operative habilitation at Blythedale Children's Hospitalmarker in Valhalla, New Yorkmarker (Westchester Countymarker).

The Aguirre brothers and their mother now live in a donated house in Scarsdale, New Yorkmarker. The twins continue to attend physical therapy at Blythedale. As of December 2005, Clarence can walk short distances unassisted, and Carl can walk with a walker. Considering the neurological and mechanical challenges they have faced, their habilitation has been remarkable.

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