"Disease" is the first single from Matchbox Twenty's third album, More Than You Think You Are. It was co-written by Matchbox Twenty lead singer Rob Thomas and The Rolling Stones frontman Mick Jagger. It had some success on rock and alternative charts, though—owing to its relatively hard rock sound—it was not as successful on mainstream pop charts as some of Matchbox Twenty's other singles (peaking at #29 on the Billboard Hot 100).

Music video

The video, directed by Phil Harder, starts with a male child turning on his colorful beatbox, then roller skating over a wide section of New York City, with some images on billboards of 1st Rob, then later the whole band (albeit on separate billboards). At the 2nd chorus, we see the band performing in what appears ironically enough to be a disco hall, complete with ball. They are surrounded by a crowd dancing along, and to begin the 3rd chorus, Rob slides off the stage on all fours onto the dance floor past the crowd. At the end of the song, the roller skater shuts off his beat box and then proceeds up some stairs, presumably to his home.

Chart positions

Charts	Peak position
Australian ARIA Singles Chart	31
U.S. Billboard Hot 100	29
U.S. Billboard Modern Rock Tracks	21
U.S. Billboard Adult Top 40	4
U.S. Billboard Top 40 Mainstream	15
UK Singles Chart	50

Track Listing

• Ultimate Main Mix

1. "Disease" (Ultimate Main mix)- 3:40