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More info on HLA-DR3

HLA-DR3: Map

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major histocompatibility complex, class II, DR3
Haplotypes groups DRA*01:DRB1*0301 DRA*01:DRB1*0302 DRA*01:DRB1*0303 DRA*01:DRB1*0304
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol HLA-DRA
EBI-HLAmarker DRA*0101
Identifiers
beta 1 *0301 *0301 *0302 *0303 *0304
Symbol HLA-DRB1
EBI-HLAmarker DRB1*0301
EBI-HLAmarker DRB1*0302
EBI-HLAmarker DRB1*0303
EBI-HLAmarker DRB1*0304
EBI-HLAmarker DRB1*0305
Shared data
Locus chr.6 6p21.31


HLA-DR3 is composed to the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.

Serology

DR17 and DR3 recognition of some DRB1*03 alleles
DRB1* DR3 DR17 DR18 Sample
allele % % % size (N)
0301 33 64 0 9698
0302 24 3 66 317
0303 40 60 5
0304 60 20 5
0307 >50 1


Some DR3 also react with HLA-DR17 and/or HLA-DR18. The DRB1*0304 primarily reacts with DR3. The serotypes of *0305, *0306, *0308 to *0331 are unknown.

Disease associations

By serotype

HLA-DR3 is associated with early-age onset myasthenia gravis, Hashimoto's thyroiditis (along with DR5), primary sclerosing cholangitis, and opportunistic infections in AIDS, but lowered risk for cancers.

By allele

DRB1*0301 (see HLA-DR17)

DRB1*0302 (See HLA-DR18)

DRB1*0304 is associated it graves disease

By haplotypes

DR3 and/or DQ2 is associated with Moreen's ulceration, "bout onset" multiple sclerosis, Grave's disease and systemic lupus erythematosus

DR3-DQ2 linkage is associated with coeliac disease, dermatitis herpetiformis, juvenile diabetes. DR3-DR2 is the serological marker for HLA-DQ2.5cis isoform. Although it cannot identify the alpha ".5" chain of HLA DQ, DQA1*0501 gene is almost always found within the DR3-DQ2 haplotype Eurasia (however is older studies DQA1*0505 is commonly confused with DQA1*0501)



Genetic linkage

DR3 is genetically linked to HLA-DR52, DRB3*0202 allele, and HLA-DQ2 (DQ2.5).

References

  1. derived from IMGT/HLA



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