In the U.S. state of Tennessee, Interstate 75 runs from Chattanooga to Jellico by way of Knoxville. Interstate 75 enters the East Tennessee region following the Tennessee Valley from Georgia, all the way through Knoxville to near Lake City, then climbs into the Cumberland Mountains before crossing over into Kentucky.

Interstate 75 originally continued into downtown Knoxville then turned to the north at Malfunction Junction, following what is now signed as Interstate 275. When the western section of Interstate 640 was completed in 1982, Interstate 75 was moved to overlap the auxiliary route to divert through traffic away from downtown in preparation for the 1982 World's Fair. This concurrency is somewhat unusual in that the exit numbers and mile markers follow the auxiliary route I-640 instead of Interstate 75 milage.

In December 1990, a 99 vehicle accident occurred in dense fog outside Calhoun that resulted in 12 deaths and 42 injuries. The accident was later profiled on the show Forensic Files.

In March 2005, the southbound lanes of Interstate 75 were shut down between mile marker 141 to 143 in Campbell County due to a rockslide below the roadway that caused the pavement to partially collapse.

On May 1, 2008 I-75 Northbound traffic was re-routed back along its original path in downtown Knoxville along Interstate 275 as part of SmartFix 40, a major construction project that includes closing a portion of I-40. Traffic was re-routed along I-275 as the ramp from I-640 Eastbound/I-75 Northbound to I-75 Northbound is only one lane which causes traffic delays at peak times.

Lane configurations

• Between Kentucky line and Exit 112 (2 lanes on each side)
• From Exit 112 to I-275/I-640 interchange (3 lanes on each side)
• Along I-640 concurrency (3 to 4 lanes each way)
• From I-40/I-640 western split to I-140 (Exit 376) (4 to 5 lanes each way)
• From I-140 to I-40/I-75 split west of Farragut (3 lanes each way)
• From I-40 to Exit 7 (SR 317 near Chattanooga) (2 lanes each way)
• From Exit 7 to SR 153 (Exit 3) (4 lanes each way)
• From SR 153 to I-24 (3 lanes each way)
• Through I-24 interchange (2 lanes each way)
• From EB 24 to SB 75 ramp to Georgia line (3 through lanes each way, auxiliary lane SB for US 41 exit)

Exit list

County	Location	Mile	#	Destinations	Notes
Hamilton	Chattanooga		1		Signed as exits 1A (south) and 1B (north) northbound
			2	, Birmingham	South end of US-74 overlap
			3		Signed as exits 3A (east) and 3B (west) northbound
			4
			4A	Hamilton Place Boulevard	Northbound exit and southbound entrance
			5	Shallowford Road
			7		South end of US-11/US-64/SR-2 overlap; signed as exits 7A (SR-317 east) and 7B (SR-317 west) northbound
			9	Volunteer Ordnance Road
			11		North end of US-11/US-64/SR-2 overlap
Bradley			20		North end of US-74 overlap
	Cleveland		25	, Lee University
			27
			33
McMinn			36
			42
	Athens		49
			52	Mount Verd Road (SR-305) – Athens
			56
Monroe	Sweetwater		60
			62
Loudon			68
	Loudon		72
	Bridge over the Tennessee River
			76
	Lenoir City		81
	Begin concurrency
			84B		South end of I-40 overlap; no exit number southbound
Knox			369	Watt Road
	Farragut		373	Campbell Station Road – Farragut
	Knoxville		374
			376		Signed as exits 376A (north) and 376B (east)
			378	Cedar Bluff Road	Signed as exits 378A (south) and 378B (north) southbound
			379	Bridgewater Road, Walker Springs Road, Gallaher View Road	Signed as exits 379 (Bridgewater Road, Walker Springs Road) and 379A (Gallaher View Road) southbound
			380	Kingston Turnpike
			383	Papermill Drive (SR-332)
					North end of I-40 overlap; south end of I-640 overlap
		End ] concurrency Begin
			1
			3B		Northbound exit and southbound entrance
			3	– Asheville	North end of I-640 overlap; no exit number northbound
		End concurrency
			3		No exit number southbound
		108	Merchants Drive
			110	Callahan Drive, Dante Drive
			112
		117
Anderson			122
	Lake City		128
			129		South end of US-25W/SR-9 overlap
Campbell	Caryville		134		North end of US-25W/SR-9 overlap; south end of SR-63 overlap
			141		North end of SR-63 overlap
			144	Stinking Creek Road
			156	Rarity Mountain Road
	Jellico		160

References