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Jean-Baptiste Denys (c. 1640–1704) was a Frenchmarker physician. He studied in Montpelliermarker and was the personal physician to King Louis XIV.

On June 15, 1667, Jean-Baptiste Denys administered the first fully-documented human blood transfusion. A 15-year-old boy bled too many times to count by other doctors because of a fever was given nine ounces of lamb's blood; he partially recovered, but then he died. There have not been since, it appears, any subsequent successful blood transfusion operations between species of such widely divergent man calfs taxonomic rank.

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