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In United States law, select agents are pathogens or biological toxins which have been declared by the U.S. Department of Health and Human Services or by the U.S.marker Department of Agriculturemarker to have the "potential to pose a severe threat to public health and safety". The Centers for Disease Control administers the Select Agent Program, which regulates the laboratories which may possess, use, or transfer select agents within the United States. The Select Agent Program was established to satisfy requirements of the USA PATRIOT Act and the Public Health Security and Bioterrorism Preparedness and Response Act of 2002, which were enacted in the wake of the September 11, 2001 attacks and the subsequent 2001 anthrax attacks.

The active use of select agents in biomedical research prompts concerns about dual use. The federal government has created the National Science Advisory Board for Biosecurity, a critical component of a set of federal initiatives to promote biosecurity in life science research. This advisory board is composed of government, education and industry subject matter experts who provide policy recommendations on ways to minimize the possibility that knowledge and technologies emanating from vitally important biological research will be misused to threaten public health or national security.

List of select agents

HHS Select Agents AND TOXINS

pandemic influenza virus]] containing any portion of thecoding regions of all eight gene segments (Reconstructed1918 Influenza virus)

Central European Tick-borne encephalitisFar Eastern Tick-borne encephalitisKyasanur Forest diseaseOmsk Hemorrhagic FeverRussian Spring and Summer encephalitis


Bacillus anthracis

Brucella abortus

Brucella melitensis

Brucella suis

Burkholderia mallei (formerly Pseudomonas mallei)

Burkholderia pseudomallei (formerly Pseudomonas pseudomallei)

Hendra virus

Nipah virus

Rift Valley fever virus

Venezuelan Equine Encephalitis virus


African horse sickness virus

African swine fever virus

Akabane virus

Avian influenza virus (highly pathogenic)

Bluetongue virus (exotic)

Bovine spongiform encephalopathy agent

Camel pox virus

Classical swine fever virus

Ehrlichia ruminantium (Heartwater)

Foot-and-mouth disease virus

Goat pox virus

Japanese encephalitis virus

Lumpy skin disease virus

Malignant catarrhal fever virus(Alcelaphine herpesvirus type 1)

Menangle virus

Mycoplasma capricolum subspecies capripneumoniae(contagious caprine pleuropneumonia)

Mycoplasma mycoides subspecies mycoides small colony (Mmm SC) (contagious bovine pleuropneumonia)

Peste des petits ruminants virus

Rinderpest virus

Sheep pox virus

Swine vesicular disease virus

Vesicular stomatitis virus (exotic): Indiana subtypesVSV-IN2, VSV-IN3

Virulent Newcastle disease virus 1


Peronosclerospora philippinensis (Peronosclerosporasacchari)

Phoma glycinicola (formerly Pyrenochaeta glycines)

Ralstonia solanacearum race 3, biovar 2

Rathayibacter toxicus

Sclerophthora rayssiae var zeae

Synchytrium endobioticum

Xanthomonas oryzae

Xylella fastidiosa (citrus variegated chlorosis strain)

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