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TFMFly is a compound related to phenethylamine hallucinogen such as 2C-B-FLY and 2C-TFM. It was first reported in 2005 by a team at Purdue Universitymarker led by David Nichols. It acts as a potent agonist at the 5HT2A serotonin receptor subtype, and is a chiral compound with the more active (R) enantiomer having a Ki of 0.12nM at the human 5HT2A receptor. While the fully aromatic benzodifurans such as bromodragonfly generally have higher binding affinity than saturated compounds like 2C-B-FLY, the saturated compounds have higher efficacy as agonists.

References

  1. Michael Robert Braden PhD. Towards a biophysical understanding of hallucinogen action. Purdue University 2007.
  2. Ralf Heim PhD. Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts. (German)



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