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Thebaine (paramorphine) is an opiate alkaloid. A minor constituent of opium, thebaine is chemically similar to both morphine and codeine, but has stimulatory rather than depressant effects, causing strychnine-like convulsions at higher doses. Thebaine is not used therapeutically, but can be converted industrially into a variety of compounds including oxycodone, oxymorphone, nalbuphine, naloxone, naltrexone, buprenorphine and etorphine.

It is controlled under international law, is listed as a Class A drug under the Misuse of Drugs Act 1971 in the United Kingdommarker and is controlled as a Schedule II of the Controlled Substances Act in the United States of Americamarker.

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