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Unisom is the Chattem brand name for an over-the-counter sleep-aid medication. While marketed under a single trademark, the active ingredient may be one of two drugs, depending on the type of preparation. Doxylamine succinate is sold in 25 mg dosages as tablets, and diphenhydramine hydrochloride is sold as tablets, and also in liquid/gelatin preparation in dosages of 50 mg.

Unisom (Doxylamine) has been known to treat a pregnancy condition called hyperemesis gravidarum. For more extreme cases, a doctor would normally recommend 2 pills per day: 1/2 (12.5mg) in the morning, the same 6 hours later and a whole pill just before bed. Each dose of the Unisom is combined with a 25mg dose of a B6 vitamin.


On January 2, 2007, Chattem, Inc. acquired five over-the-counter name brands from Johnson & Johnsonmarker, including Unisom. The Unisom brand was acquired by Johnson & Johnson in 2006 from Pfizer Consumer Healthcare.


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